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Synlett 1998; 1998(2): 143-144
DOI: 10.1055/s-1998-1595
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Stereoselective Nickel and Manganese Catalyzed Cyclizations of 5-Haloketones

Thomas Stüdemann* , Malika Ibrahim-Ouali, Gérard Cahiez, Paul Knochel
  • *Fachbereich Chemie der Philipps-Universität Marburg, 35032 Marburg, Germany; Fax 00 49-64 21-28 21 89; E-mail: Knochel@ps1515.chemie.uni-marburg.de
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Publication History

Publication Date:
31 December 2000 (online)

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The treatment of various 5-iodoketones or 5-bromoketones with Et2Zn in the presence of either Ni(acac)2 (5 mol %) or MnBr2/CuCl (5 mol %) produces functionalized substituted cyclopentanols bearing in some cases contiguous quaternary centers with high stereoselectivity.

cyclization - stereoselectivity - Et2Zn - Ni(acac)2 - MnBr2/CuCl

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