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Synlett 1998; 1998(1): 47-48
DOI: 10.1055/s-1998-1057884
DOI: 10.1055/s-1998-1057884
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A New Methodology for the Reductive Cyclization of ω-Azido Carbonyl Compounds Mediated by Tetrathiomolybdate: Application to an Efficient Synthesis of Pyrrolo[2,1-c][1,4]benzodiazepines
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Publication History
Publication Date:
06 February 2008 (online)
The ω-azido carbonyl compounds on treatment with tetrathiomolybdate, 1 led to the formation of 5, 6 and 7 membered cyclic imines in very good yields under mild conditions. This method is applied successfully to a new efficient synthesis of 1,4-benzodiazapinone derivatives and in particular Bzl DC-81.
tetrathiomolybdate - ω-azidocarbonyl compounds - reductive cyclization - pyrrolobenzodiazepines