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Synlett 1997; 1997(8): 965-967
DOI: 10.1055/s-1997-957
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Stereospecific Syntheses of Michellamines A and C

Peter D. Hobbs, Velaparthi Upender, Marcia I. Dawson*
  • *SRI International, Pharmaceutical Discovery Division, 333 Ravenswood Avenue, Menlo Park, CA 94025, USA, Fax 01-415-859-3153; e-mail marcia_dawson@qm.sri.com
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Publication History

Publication Date:
31 December 2000 (online)

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The total syntheses of two of the three dimeric naphthylisoquinoline michellamines - A and C - were achieved by Pd-catalyzed cross-coupling of the appropriate 6'-bromo- or 6'-boronic acid-substituted tetrabenzylated korupsensamine A and B derivatives under nonaqueous conditions, followed by deprotection of the octabenzylated products.

naphthylisoquinoline alkaloids - michellamines - korupensamines - atropdiasteromer - Suzuki hetero-biaryl coupling

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