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Synthesis 1997; 1997(11): 1321-1324
DOI: 10.1055/s-1997-1354
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A Convenient and Regioselective Synthesis of 4-Trifluoromethylpyridines

Isamu Katsuyama, Seiya Ogawa, Yoshihiro Yamaguchi, Kazumasa Funabiki, Masaki Matsui, Hiroshige Muramatsu, Katsuyoshi Shibata*
  • *Department of Chemistry, Faculty of Engineering, Gifu University, Yanagido, Gifu 501-11, Japan, Fax +81(58)2301893
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Publication History

Publication Date:
31 December 2000 (online)

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Trifluoromethyl-substituted β-diketones regioselectively react with primary enamines such as β-aminocrotononitrile and ethyl β-aminocrotonate, providing moderate to good yields of 4-trifluoro-methylpyridines.

trifluoromethyl - β-diketones - β-aminocrotononitrile - ethyl β-aminocrotonate - 4-trifluorometehylpyridines

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