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Synthesis 1997; 1997(10): 1169-1173
DOI: 10.1055/s-1997-1326
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Nucleophilic Reactions in the Pyrrole Series: Displacement of Halogen as a Tool to Functionalize the Pyrrole Nucleus

G. Cirrincione1 , A. M. Almerico2 , A. Passannanti2 , P. Diana2 , F. Mingoia3
  • 1Istituto Farmacochimico dell’Università, Via Archirafi 32, 90123 Palermo, Italy, Fax +39(91)6169999; E-mail: farmachim@mbox.unipa.it
  • 2Istituto Farmacochimico dell’Università, Via Archirafi 32, 90123 Palermo, Italy
  • 3Istituto di Chimica e Tecnologia die Prodotti Naturali-C.N.R., Via Archirafi 22-26, 90123 Palermo, Italy, Fax +39(91)6166281; E-mail: ictpn@ipacuc.cuc.unipa.it
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Publication Date:
31 December 2000 (online)

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Nucleophilic substitutions on halopyrroles by charged and neutral carbon, nitrogen, oxygen and sulfur nucleophiles are reported. Such reactions represent a valuable and versatile instrument to prepare a wide variety of functionalized pyrroles and to obtain building blocks for the synthesis of polycyclic systems.

nucleophilic substitutions - halopyrroles - carbon - nitrogen - oxygen and sulfur nucleophiles

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