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Synlett 1996; 1996(9): 875-876
DOI: 10.1055/s-1996-5616
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An Improved Method for the One-Carbon Homologation of Ketones with Acidic α-Hydrogens

Daniel Mink, Ghislain Deslongchamps*
  • *Department of Chemistry, University of New Brunswick, Fredericton N.B., E3B 6E2, Canada, Fax (506) 453-4981, e-mail: ghislain@unb.ca
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Publication History

Publication Date:
31 December 2000 (online)

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A simple and efficient one-carbon homologation of ketones containing acidic α-hydrogens via a low basicity Horner-Emmons reagent is described. The reaction produces the corresponding ketene dithioacetals, which are highly versatile synthetic intermediates.

Ketene Dithioacetal - Horner-Emmons Reaction - One-Carbon Homologation - Acidic α-Hydrogens - Ketones

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