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Synlett 1996; 1996(9): 873-874
DOI: 10.1055/s-1996-5587
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Remarkable Fast Microwave-assisted N-Alkylation of Phthalimide in Dry Media

Dariusz Bogdał* , Jan Pielichowski, Adam Boroń
  • *Institute of Organic Chemistry, Politechnika Krakowska, ul. Warszawska 24, 31-155 Kraków, Poland, Fax: +48 12 34-24-25; E-mail: pcbogdal@kinga.cyf-kr.edu.pl
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Publication Date:
31 December 2000 (online)

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A new method of synthesis of N-alkylphthalimides via alkylation of phthalimide in ‘dry’ media under microwave irradiation has been elaborated. The reactions were carried out with high yield (49-95%) by simply mixing of phthalimide with an alkyl halide which was adsorbed on potassium carbonate. The irradiation of the mixtures in a domestic microwave oven leads in a remarkable short time (4-10 min) to the desired N-alkylphthalimides.

phthalimide - alkylation - microwave - dry media

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