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Synlett 1996; 1996(5): 433-434
DOI: 10.1055/s-1996-5461
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Total Synthesis of Galtamycinone, the Common Aglycon of the C-Glycosyl Naphthacenequinone Antibiotics

Takashi Matsumoto, Hiroki Yamaguchi, Keisuke Suzuki*
  • *Department of Chemistry, Keio University, Hiyoshi, Kohoku-ku, Yokohama 223, Japan
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Publication Date:
31 December 2000 (online)

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Total synthesis of galtamycinone (1), the common structure in the C-glycosyl naphthacenequinone-class antibiotics, is described. The key step is the base-promoted regioselective cycloaddition of C-glycosyl chloronaphthoquinone 2 with homophthalic anhydride 6.

Total synthesis - Naphthacenequinone - Antibiotic - Aryl C-glycoside - Cycloaddition

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