Download PDF
Synlett 1996; 1996(4): 353-355
DOI: 10.1055/s-1996-5438
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Novel Phthalimidine Synthesis. Mannich Condensation of o-Phthalaldehyde with Primary Amines using 1,2,3-1H-Benzotriazole and 2-Mercaptoethanol as Dual Synthetic Auxiliaries

Ichiro Takahashi* , Teruki Kawakami, Etsushi Hirano, Hiroshi Yokota, Hidehiko Kitajima
  • *Department of Applied Chemistry and Biotechnology, Faculty of Engineering, Fukui University, Bunkyo 3-9-1, Fukui 910, Japan, (Fax) 81-776-27-8761, (E-mail) ichiro@acbio.acbio.fukui-u.ac.jp
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

The 1:1 condensation reactions of o-phthalaldehyde with a variety of primary amines in the presence of excess 2-mercaptoethanol and 1,2,3-1H-benzotriazole as ”dual synthetic auxiliaries” in MeCN for 13 h at room temperature afford 2-substituted phthalimidines (2,3-dihydroisoindol-1-ones) in fair to good isolated yields.

phthalimidine - Mannich condensation - dual synthetic auxiliaries

      >