Download PDF
Synlett 1996; 1996(1): 95-96
DOI: 10.1055/s-1996-5333
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

A Short Synthesis of Phenyl Kainoid

Manabu Horikawa, Haruhisa Shirahama*
  • *Department of Chemistry, Faculty of Science, Hokkaido University, Sapporo 060, Japan
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

A phenyl kainoid, (2S,3R,4S)-3-carboxymethyl-4-phenylproline (5), was synthesized from (2S,4R)-4-hydroxyproline through the oxidative radical addition of malonic monoester to Δ3-dehydroproline 8 using manganese(III) acetate.

Phenyl kainoid - Glutamate agonist - Oxidative radical addition - Manganese(III) acetate - Acromelic acid

      >