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Synlett 1996; 1996(1): 103-104
DOI: 10.1055/s-1996-5328
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Synthesis of the C1-C8 Tetrahydropyranyl Segment of the Antifungal Agent Ambruticin and its C3 Epimer

Luping Liu, William A. Donaldson*
  • *Dept. of Chemistry, Marquette University, Milwaukee, WI 53233, USA
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Publication Date:
31 December 2000 (online)

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The synthesis of the C1-C8 segment (2) of ambruticin and its C3 epimer (9), were accomplished starting from the diethyldithioacetal of L-arabinose in 10 and 8 steps (10% and 16% yield) respectively.

The synthesis of the C1-C8 segment (2) of ambruticin and its C3 epimer (9), were accomplished starting from the diethyldithioacetal of L-arabinose in 10 and 8 steps (10% and 16% yield) respectively.

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