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Synthesis 1996; 1996(12): 1494-1498
DOI: 10.1055/s-1996-4419
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An Improved Synthesis of Dichloroalkylphosphonates, Chloroalkynes and Terminal Alkynes via Diethyl Dichloromethylphosphonate

John Carran, Rachel Waschbüsch, Angela Marinetti, Philippe Savignac*
  • *Hétéroatomes et Coordination, URA CNRS 1499, DCPH, Ecole Polytechnique, F-91128 Palaiseau Cedex, France, Fax +33(1)69333990
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Publication Date:
31 December 2000 (online)

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Diethyl 1,1-dichloromethylphosphonate (2) was synthesised in good yield from the reduction of 1,1,1-trichloromethylphosphonate (1) with i-C3H7MgCl and subsequent hydrolysis. The reactivity of 2 towards α-alkylation and its utility in the synthesis of chloroalkynes and terminal alkynes was investigated.

1,1-dichloromethylphosphonate - 1,1-dichloroalkylphosphonates - alkynes - chloroalkynes - magnesium

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