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Synthesis 1996; 1996(11): 1280-1282
DOI: 10.1055/s-1996-4389
short paper
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A New Protocol for the Conversion of Isoxazolidines to 1,3-Amino Alcohols

Gianluigi Broggini* , Gaetano Zecchi
  • *Dipartimento di Chimica Organica e Industriale dell’Università, via Golgi 19, I-20133 Milano, Italy, Fax +39(2)2364369
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Publication Date:
31 December 2000 (online)

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A number of fused-ring isoxazolidines 3 have been successfully transformed into the corresponding 1,3-amino alcohols 5 through oxidation with 3-chloroperbenzoic acid and subsequent catalytic hydrogenation.

intramolecular 1,3-dipolar cycloaddition - isoxazolidines - 1,3-amino alcohols - nitrones - hydrogenolysis

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