Download PDF
Synthesis 1996; 1996(8): 997-1001
DOI: 10.1055/s-1996-4327
paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Synthesis of 2-Substituted 6-Fluoroalkylpyrimidin-4(3H)-ones and -pyrimidines

Hui-Ping Guan, Qiao-Sheng Hu, Chang-Ming Hu*
  • *Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, People’s Republic of China, Fax +86(21)64166128
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

Treatment of ethyl α-fluoroalkylacetates 1 or ethyl 3-fluoroalkyl-2-iodoacrylates 2 under mild conditions with amidine affords 2-substituted 6-fluoroalkylpyrimidin-4(3H)-ones 4, 5, 6, 7 in excellent yields, while α-fluoroalkyl alkyl ketones or α-fluoroalkyl aldehyde 3 give polysubstituted 6-fluoroalkylpyrimidines 8, 9 under the same conditions.

synthesis of fluoroalkylpyrimidones and -pyrimidines - fluoroalkylcarbonyl compounds - 3-fluoroalkyl-2-iodoacrylates - amidine

      >