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Synthesis 1996; 1996(7): 871-876
DOI: 10.1055/s-1996-4306
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An Efficient Synthesis of Substituted 3(4)-Nitropyrroles from Nitroalkenes and Tosylmethyl Isocyanides

Ronald ten Have, Frederik R. Leusink, Albert M. van Leusen*
  • *Department of Organic and Molecular Inorganic Chemistry, Groningen Centre for Catalysis and Synthesis, Groningen University, Nijenborgh 4, NL-9747 AG Groningen, The Netherlands, Fax +31503634296
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Publication Date:
31 December 2000 (online)

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A series of 3(4)-nitropyrroles with alkenyl substituents in the 2- and 3-positions (or 3-position only) is synthesized efficiently in one operation by a base-induced addition of tosylmethyl isocyanide (TosMIC), or unsaturated homologs of TosMIC, to nitroalkenes.

Pyrrole ring construction by C2C3 and C4C5 bond formation

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