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Synthesis 1996; 1996(2): 259-264
DOI: 10.1055/s-1996-4193
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Synthesis of 1,1-Dibromo-3-hydroxyalkanes via Opening of Cyclic Sulfates

Hans Christian Stiasny*
  • *Fachbereich Chemie der Philipps-Universität Marburg, Hans-Meerwein-Strasse, D-35032 Marburg, Germany
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Publication History

Publication Date:
31 December 2000 (online)

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3-Alkoxy-1,1-dibromoalkanes are interesting substrates for diastereoselective bromine/lithium exchange reactions. A general route to the precursor 1,1-dibromo-3-hydroxyalkanes is described here via reaction of dibromomethyllithium with cyclic sulfates of 1,2-diols.

1,2-diols - cyclic sulfates - dibromomethyllithium - 1,1-dibromo-3-hydroxyalkanes

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