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Synlett 1995; 1995(11): 1127-1128
DOI: 10.1055/s-1995-5218
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Methyl Carboxymethylenation of Alcohols via Dehydrative Alkylation

Jurong Yu, Jing-Yu Lai, J. R. Falck*
  • *Departments of Molecular Genetics and Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
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Publication Date:
31 December 2000 (online)

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Dehydrative alkylation of alcohols with methyl phenylsulfonylacetate under modified Mitsunobu conditions followed by desulfonylation using magnesium affords two-carbon elongated methyl carboxylates in good to excellent yields. Diols and bromoalcohols furnish cycloalkylcarboxylates.

Mitsunobu - carboxylation - desulfonylation - C-C bond formation

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