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Synlett 1995; 1995(10): 1043-1044
DOI: 10.1055/s-1995-5182
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Efficient Synthesis of Chiral Propargyl Alcohols by Enantioselective Titanium-TADDOLate Catalyzed Addition of Dimethylzinc to 3-Trimethylsilyl-2-propynal

Nobuki Oguni* , Nobuyuki Satoh, Hiroyuki Fujii
  • *Department of Chemistry, Faculty of Science, Yamaguchi University, Yamaguchi City, Yamaguchi 753, Japan
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Publication Date:
31 December 2000 (online)

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A practical and efficient synthesis of chiral propargyl alcohols was achieved by the enantioselective addition of dimethylzinc to 3-trimethylsilyl (TMS)-2-propynal (5) using titanium-TADDOLate (α,α,α’,α’-tetraaryl-2,2-disubstituted-1,3-dioxolane-4,5-dimethanolate) catalysts.

Catalytic Asymmetric Methylation - Dimethylzinc - Titanium-TADDOLate Catalyst

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