Download PDF
Synlett 1995; 1995(8): 819-820
DOI: 10.1055/s-1995-5092
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Improved Preparation of Enantiomerically Pure 5-Oxo Amino Acid Derivatives by Palladium-Catalysed Coupling Reactions

Joanne L. Fraser, Richard F. W. Jackson* , Barry Porter
  • *Department of Chemistry, Bedson Building, The University of Newcastle, Newcastle upon Tyne, NE1 7RU, UK
Further Information

Publication History

Publication Date:
31 December 2000 (online)

  PDF Download  Permissions and Reprints All articles of this category

The organozinc reagent 3 reacts with unfunctionalised acid chlorides under palladium catalysis to give enantiomerically pure protected 5-oxo amino acids in good to excellent yields, provided dimethoxyethane (DME) is used as solvent. For functionalised acid chlorides, the solvent systems benzene/dimethylacetamide (DMA) or toluene/DMA are preferred.

α-amino acids - organozinc reagents - palladium catalysed cross-coupling - 5-oxo amino acids

      >