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Synlett 1995; 1995(1): 38-40
DOI: 10.1055/s-1995-4851
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On the Role of the Nitrogen Atom in Dynemicin A

Martin E. Maier* , Ulrich Abel
  • *Martin-Luther-Universität Halle-Wittenberg, Fachbereich Chemie, Institut für Organische Chemie, Weinbergweg 16, 06120 Halle (Saale), Germany
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Publication Date:
31 December 2000 (online)

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The dynemicin analogs 13a,b have been synthesized from the cyclohexenone derivative 8b via the enediyne aldehyde 12. NMR analysis indicates that 13a,b exist as rotamers around the C-aryl bond. This points to the role of the nitrogen atom in dynemicin A for fixation of the conformation of the aryl ring.

dynemicin analog - [7.3.1.]-enediynes - rotamers

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