Download PDF
Synthesis 1994; 1994(7): 695-697
DOI: 10.1055/s-1994-25549
short paper
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Regiospecific Synthesis of α-Amino Keto Acetals (β,β-Dialkoxyamines)

Norbert De Kimpe* , Elena Stanoeva
  • *Department of Organic Chemistry, Faculty of Agricultural and Applied Biological Sciences, University of Gent, Coupure Links 653, B-9000 Gent, Belgium
Further Information

Publication History

Publication Date:
17 September 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

α-Amino keto acetals (β,β-dialkoxyamines) are synthesized in a regiospecific way by the reaction of α-bromo-α-chloro ketimines with sodium borohydride in methanol. As α-bromo-α-chloro ketimines are formed regiospecifically from α,α-dihalogenated ketones, derived from the corresponding ketones, this methodology entails a regiospecific synthesis of α-amino keto acetals from ketones.

      >