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Synlett 1994; 1994(11): 943-945
DOI: 10.1055/s-1994-23058
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A New Synthesis of γ-Butyrolactones via Palladium(II)-Catalyzed Cyclization of Trimethylsilylalkynes

Philippe Compain* , Jean-Michel Vatèle, Jacques Goré
  • *Laboratoire de Chimie Organique 1, associé au CNRS, Université Claude Bernard, ESCIL, 43 Bd du 11 Novembre 1918, 69622 Villeurbanne, France.
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Publication Date:
22 March 2002 (online)

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In the presence of CuCl2 and O2, palladium(II)-catalyzed cyclization of 1-substituted 4-(trimethylsilyl)-3-butyn-1-ols produced γ-butyrolactones in satisfactory yields (50-74%). The effect of experimental parameters on the yield and on the reaction time has been studied. The best results were obtained by using Pd(OAc)2 or PdClNO2(CH3CN)2 as catalysts and a mixture of CH3CN and 1N HCl as solvent.

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