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Synlett 1994; 1994(5): 368-370
DOI: 10.1055/s-1994-22857
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A Practical Synthesis of Geometrically Pure N-Boc-Protected Primary Allylic Amines

Rolf A. T. M. van Benthem* , Jasper J. Michels, Henk Hiemstra, W. Nico Speckamp
  • *Laboratory of Organic Chemistry, University of Amsterdam, Nieuwe Achtergracht 129, 1018 WS Amsterdam, The Netherlands
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Publication Date:
22 March 2002 (online)

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N-Boc-Protected primary allylic amines are easily prepared from the corresponding mesylates or halides by using di-tert-butyl imidodicarbonate (Boc2NH) and K2CO3 or Cs2CO3 in a Gabriel-type substitution, followed by selective removal of one Boc group with TFA.

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