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Synlett 1994; 1994(4): 263-265
DOI: 10.1055/s-1994-22820
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Synthesis of Novel Azole Antifungals by a Modified Sharpless Asymmetric Dihydroxylation

Paul Blundell* , Ashit K. Ganguly, Viyyoor M. Girijavallabhan
  • *Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033 USA
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Publication Date:
22 March 2002 (online)

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An improved synthesis of the azole antifungal building block (Figure), exemplified by a formal synthesis of Sch 45450, is described. Asymmetric induction was achieved by a modified Sharpless dihydroxylation (AD) reaction which generated products with excellent enantiomeric excess.

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