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Synlett 1994; 1994(1): 65-67
DOI: 10.1055/s-1994-22740
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Selective Enzymatic Deprotection of Hydroxy- and Amino Groups in Carbohydrates and Nucleosides

H. Waldmann* , A. Heuser, A. Reidel
  • *Universität Karlsruhe, Institut für Organische Chemie, Richard-Willstätter-Allee 2, D-76128 Karlsruhe, Germany
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Publication Date:
22 March 2002 (online)

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The enzyme acetyl esterase from the flavedo of oranges (EC 3.1.1.6) chemo- and regioselectively removes acetyl groups from carbohydrates and nucleosides. The chemoselective enzymatic liberation of the amino functions present in the nucleobases of O-acetylated nucleosides is achieved by penicillin G acylase (EC 3.5.1.11) mediated hydrolysis of the corresponding phenylacetamides.

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