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Synlett 1993; 1993(9): 703-704
DOI: 10.1055/s-1993-22579
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The Synthesis of Novel HIV-Protease Inhibitors via Silica Gel Assisted Addition of Amines to Epoxides

Frank Bennett* , Naginbhai M. Patel, Viyyoor M. Girijavallabhan, Ashit K. Ganguly
  • *Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, USA
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Publication History

Publication Date:
19 March 2002 (online)

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HIV-protease inhibitors, containing novel ß-hydroxy secondary amine transition state isosteres, are constructed using a silica gel mediated addition of unreactive amines to epoxides as the key step.

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