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Synlett 1993; 1993(7): 535-538
DOI: 10.1055/s-1993-22520
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Synthetic Studies of the Rutamycins. Construction of the C1-C15 Subunit of Rutamycin B

James D. White* , Warren J. Porter, Thomas Tiller
  • *Department of Chemistry, Oregon State University, Corvallis, OR 9733-4003, USA
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Publication History

Publication Date:
19 March 2002 (online)

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The linear, polypropionate portion of the macrolide antibiotic rutamycin B was synthesized by stereoselective, aldol condensation of a ketone and an aldehyde comprising C1-C8 and C9-C15 segments, respectively. Both subunits originated from (R)-3-hydroxy-2-methylpropionate, which was elaborated using crotylstannane and asymmetric crotylboronate methodology.

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