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Synlett 1993; 1993(7): 475-477
DOI: 10.1055/s-1993-22496
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Asymmetric Synthesis of Anti N-Boc-α-Hydrazino-β-Hydroxyesters from β-Ketoesters by Sequential Catalytic Hydrogenation and Electrophilic Amination

Christine Greck* , Laurent Bischoff, Franck Ferreira, Catherine Pinel, Eric Piveteau, Jean Pierre Genêt
  • *Ecole Nationale Supérieure de Chimie de Paris, Laboratoire de Synthèse Organique Associé au C.N.R.S., 11, rue Pierre et Marie Curie, F-75231 Paris Cedex 05, France
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Publication History

Publication Date:
19 March 2002 (online)

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Enantiomerically pure anti N-Boc-α-hydrazino-β-hydroxyesters were obtained from the corresponding β-ketoesters by hydrogenation with chiral Ruthenium catalysts and electrophilic amination of the β-hydroxyester with di-tert-butylazodicarboxylate (DBAD).

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