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Synlett 1992; 1992(9): 761-763
DOI: 10.1055/s-1992-21486
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A Simple Chiral Synthesis of the Taxol Side Chain

Vittorio Farina* , Sheila I. Hauck, Donald G. Walker
  • *Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, P. O. Box 5100, Wallingford, Connecticut 06492-7660, USA
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Publication Date:
08 March 2002 (online)

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We report a highly diastereoselective synthesis of (3R,4S)-3-hydroxy-4-phenyl-2-azetidinone (11) using L-threonine as a chiral template. This compound has been utilized in the partial synthesis of taxol from 10-desacetyl baccatin III (2a).

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