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Synlett 1992; 1992(8): 655-656
DOI: 10.1055/s-1992-21446
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A Facile Synthesis of 4-Arylpyridines with an Electron-Withdrawing Group on the Benzene Ring

Min-Jen Shiao* , Kang-Hsiuan Liu, Lee-Gin Lin
  • *Institute of Chemistry, Academia Sinica, Nankang, Taipei, Taiwan, Republic of China
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Publication Date:
08 March 2002 (online)

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4-Arylpyridines 5 which contain an electron-withdrawing group on the benzene ring were synthesized in moderate yields by reaction of mixed copper/zinc aryl organometallics 1 with various 1-(ethoxycarbonyl)pyridinium chlorides 2 followed by o-chloranil oxidization under reflux in toluene.

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