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Synlett 1992; 1992(7): 555-557
DOI: 10.1055/s-1992-21412
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Synthesis of Fragments of the Capsular Polysaccharide of Haemophilus Influenzae type b on Soluble Polymeric Support

A. A. Kandil* , N. Chan, P. Chong, M. Klein
  • *Connaught Center for Biotechnology Research, 1755 Steeles Ave. West, Willowdale, Ontario, M2R 3T4, Canada
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Publication Date:
08 March 2002 (online)

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An efficient method for the synthesis of fragments of the capsular polysaccharide of H. influenzae type b containing an aminoheptyl group by the phosphoramidite chemistry using polyethylene glycol monomethyl ether (PEG) as soluble polymeric support is described. The method is suitable for the preparation of pure oligomeric compounds on a relatively large scale.

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