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Synlett 1992; 1992(1): 59-60
DOI: 10.1055/s-1992-21266
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Synthesis of Thiazole-Based DNA-Targeting Molecules Aiming at Guanine Specificity

Susumu Kobayashi* , Reiko Kuroda, Takumi Watanabe, Masami Otsuka
  • *Faculty of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113, Japan
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Publication History

Publication Date:
18 September 2002 (online)

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4-(3-Dimethylsulfoniopropylaminocarbonyl)-2-[2-(4-nitrobenzoylamino)ethyl]thiazole and the corresponding bithiazole and terthiazole derivatives have been designed and prepared aiming at specific binding to the guanine bases of DNA.

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