Synlett 1991; 1991(5): 361-363
DOI: 10.1055/s-1991-34737
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Generation of Polypropionate Fragments via a Tandem Aldol-Bis-oxidation Procedure

Norman E. Pratt* , Yun-bo Zhao, Shawn Hitchcock, Kim F. Albizati
  • *Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA
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Publication History

Publication Date:
07 March 2002 (online)

A varity of β, β′ -dihydroxyketones (7 examples) have been synthesized via a one pot tandem aldol reaction of 3-pentanone. These diols were oxidized under Swern conditions to the corresponding 1,3,5-triones providing a new method for the rapid construction of skipped polyoxo compounds.

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