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Synlett 1991; 1991(12): 875-877
DOI: 10.1055/s-1991-21987
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Novel Oxygenated Derivatives of C-25 Terminal-Substituted Alkenyl Avermectins and Their Use as Intermediates

B. J. Banks* , B. R. Fenner, V. F. Voss, M. J. Witty
  • *Animal Health Discovery Research, Pfizer Central Research, Ramsgate Road, Sandwich, Kent CT13 9NJ, England
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Publication Date:
07 March 2002 (online)

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Palladium- or osmium-catalysed oxidation of 25-(1-methyl-4-butenyl)- and 25-ethenylavermectins yields aldehyde, diol and ketone derivatives. These compounds provide access, for the first time, to avermectins with a range of polar C-25 substituents containing alcohol, epoxide, ester, nitrile, amine and pyrrole functionalities.

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