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Synlett 1991; 1991(12): 873-875
DOI: 10.1055/s-1991-20908
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Preparation of Novel C-25 Alkenylavermectin Derivatives

B. J. Banks* , B. R. Fenner, V. F. Voss, M. J. Witty
  • *Animal Health Discovery Research, Pfizer Central Research, Ramsgate Road, Sandwich, Kent CT13 9NJ, England
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Publication Date:
07 March 2002 (online)

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The pyrolysis of 25-(1-methylsulphinylalkyl)avermectins provides, in good yield, novel avermectins with C-25 substituents containing terminal alkenyl groups. The use of palladium(II) acetate catalyst permits the highly selective elaboration of such compounds to more complex C-25 alkenes and their derivatives, without the use of protecting groups and in the presence of acid- and base-labile functionalities.

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