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Synlett 1991; 1991(6): 441-442
DOI: 10.1055/s-1991-20757
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Preparation of (4S)-4-Hydroxy-3-methyl-2-(2-propynyl)-2-cyclopenten-1-one by Sequential Combination of Enzymatic Hydrolysis and Mitsunobu Reaction

Hidenori Danda* , Yoshio Furukawa, Takeaki Umemura
  • *Takarazuka Research Center, Sumitomo Chemical Co., Ltd., 2-1, 4-Chome, Takatsukasa, Takarazuka, Hyogo 665, Japan
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Publication Date:
07 March 2002 (online)

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(4S)-4-Hydroxy-3-methyl-2-(2-propynyl)-2-cyclopenten-1-one, which is an important alcohol moiety of optically active pyrethroid insecticides, was prepared from the corresponding racemic acetate by the sequential combination of enzymatic hydrolysis and Mitsunobu reaction, in an excellent optical yield.

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