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Synlett 1991; 1991(2): 111-113
DOI: 10.1055/s-1991-20646
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Chiral Aminal Templates 5.1 Preparation of Chiral 1,4-Dihydropyridine-3-carboxaldehydes

R. Gosmini* , P. Mangeney, A. Alexakis, M. Commerçon, J. -F. Normant
  • *Laboratoire de Chimie des Organoéléments, Université Paris VI, Tour 44-45, 4 Place Jussieu F-75232 Paris Cedex 05, France
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Publication Date:
07 March 2002 (online)

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Organocopper reagents react with 1-acylpyridinium salts, bearing in the 3 position a chiral aminal [1-acyl-3-(trans-1,3-dimethyl-4, 5-diphenylimidazolidin-2-yl)pyridinium salts], to give after acidic hydrolysis chiral 4-substituted 1-acyl-1, 4-dihydropyridine-3-carboxaldehydes in high optical purity and in good chemical yield.

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