Download PDF
Synlett 1990; 1990(12): 751-753
DOI: 10.1055/s-1990-21238
letter
© Georg Thieme Verlag, Rüdigerstr. 14, 70469 Stuttgart, Germany. All rights reserved. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. Any use, exploitation or commercialization outside the narrow limits set by copyright legislation, without the publisher's consent, is illegal and liable to criminal prosecution. This applies in particular to photostat reproduction, copying, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.

Total Synthesis of (-)-Aristeromycin

Hans Jürgen Bestmann* , Dieter Roth
  • *Institut für Organische Chemie der Universität Erlangen-Nürnberg, Henkestraße 42, D-8520 Erlangen, Germany
Further Information

Publication History

Publication Date:
08 March 2002 (online)

  PDF Download  Permissions and Reprints All articles of this category

The carbocyclic analogue of adenosine, (-)-aristeromycin (2; 9-[1′R,2′S,3′R,4′R)-2′, 3′-dihydroxy-4′-(hydroxymethyl)-1′-cyclopentyl]-9H-purin-6-amine) is synthesized from inexpensive natural tartaric acid (3) via key intermediate 8 [(4R, 5S)-4,5-isopropylidenedioxy-3-methoxy-2-cyclopentenone]. The synthetic strategy allows the preparation of different 6-substituted analogues 17 of (-)-aristeromycin.

      >