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Synlett 1990; 1990(12): 727-728
DOI: 10.1055/s-1990-21226
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Lankacidin Synthesis: Synthesis of the Lactone Fragment and an Improved Procedure for Stereoselective Acylation of a Chiral ß-Lactam

Jane M. Roe* , Eric J. Thomas
  • *Department of Chemistry, University of Manchester, Manchester, M13 9PL, England
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Publication Date:
08 March 2002 (online)

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A synthesis of 6-membered lactone 17, the C(14)-C(6) fragment of lankacidin C (1), using an improved procedure for ß-lactam acylation is described, together with methodology for introduction of the C(10)-(13) diene.

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