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Synlett 1990; 1990(9): 508
DOI: 10.1055/s-1990-21144
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A General Method for the Synthesis of syn-(E)-3,5-Dihydroxy-6-heptenoates

George T. Lee* , Jerome Linder, Kau-Ming Chen, Kapa Prasad, Oljan Repic, Goetz E. Hardtmann
  • *Sandoz Research Institute, East Hanover, New Jersey 07936, USA
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Publication Date:
08 March 2002 (online)

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The utilization of six-carbon synthons [alkyl 3,5-bis tert-butyldiphenylsiloxy)-6-oxohexanoates] 1a-1d in the synthesis of alkyl(sodium) syn-(E)-7-[1-(4-fluorophenyl)-4-isopropyl-2-phenyl-5-imidazolyl]-3,5-dihydroxy-6-heptenoates 6a, 6b and 2b using Horner-Emmons-Wadsworth methodology is described.

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