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Synlett 1990; 1990(7): 394-396
DOI: 10.1055/s-1990-21103
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A Convenient Method for the Synthesis of 2,3-Dihydro-4H-pyran-4-ones

John R. Peterson* , Eric W. Kirchhoff
  • *Department of Pharmacognosy and the Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA
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Publication Date:
08 March 2002 (online)

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The Mukaiyama condensation of 2,4-bis(trimethylsilyloxy)-1,3-pentadienes with aldehydes and ketones in the presence of excess titanium(IV) chloride provides direct entry to functionalized 2,3-dihydro-4H-pyran-4-ones in good yield.

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