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Synlett 1990; 1990(7): 387-388
DOI: 10.1055/s-1990-21099
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An Improved Method for the Preparation of Acylhydrazines: The First Example of an Enzymatic Hydrazinolysis Reaction

Vicente Gotor* , Covadonga Astorga, Francisca Rebolledo
  • *Departamento de Química Organometálica, Facultad de Química, Universidad de Oviedo, E-33071 Oviedo, Spain
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Publication Date:
08 March 2002 (online)

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Lipases catalysed the hydrazinolysis reaction of substituted hydrazines in ethyl acetate under mild conditions to give acylhydrazides; the highest yields were obtained with hydrazines substituted with electronegative groups.

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