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Synthesis 1989; 1989(9): 719-720
DOI: 10.1055/s-1989-27374
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A Convenient Synthesis of 5-Cyano-6-dialkylamino-2-hydroxy-3-methoxycarbonyl-2-methyl-4-(2- or 4-nitrophenyl)-1,2,3,4-tetrahydropyridines and their Dehydration to 5-Cyano-6-dialkylamino-3-methoxycarbonyl-2-methyl-4-(2- or 4-nitrophenyl)-1,4-dihydropyridines

France Laure* , Jean-Claude Pascal
  • *Department of Chemistry, Recherche Syntex France, BP 40, F-91310 Montlhéry, France
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Publication Date:
17 September 2002 (online)

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The reaction of cyanoacetamidines with methyl 2-[(nitrophenyl)methylene]-3-oxobutanoates leads to 2-hydroxy-1,2,3,4-tetrahydropyridines in high yields. These compounds can be dehydrated to 1,4-dihydropyridines by heating in benzene containing a catalytic amount of p toluenesulfonic acid.

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