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Synthesis 1989; 1989(3): 182-184
DOI: 10.1055/s-1989-27188
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Low-Valent Titanium-Induced Reductive Coupling of Amino Ketones

Wei-xing Chen* , Jun-cai Feng, Zhao-lin Zhou, Jun-hu Zhang
  • *Department of Chemistry, Nanjing, University, Nanjing, People's Republic of China
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Publication Date:
17 September 2002 (online)

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The reaction of amino ketones with titanium tetrachloride/zinc powder has been studied in tetrahydrofuran and 1,4-dioxane under an argon atmosphere. Symmetrical 1,8-diaminoalkenes 2 were obtained from the corresponding Mannich base hydrochlorides 1 via the intermolecular reductive coupling, and azacycloalkenes 4 were prepared from diketoamines 3 via the intramolecular reductive coupling under similar conditions.

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