Synthesis 1988; 1988(7): 538-540
DOI: 10.1055/s-1988-27629
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A Convenient Synthesis of Enantiomerically Pure (2R,3S)- and (2S,3R)-3-Hydroxy-2-methylbutanoic Esters

Yves Petit* , Caroline Sanner, Marc Larchevêque
  • *Laboratoire de Chimie, E. R. 12 du CNRS, Ecole Normale Supérieure, 24 Rue Lhomond, F-75231 Paris Cedex 05, France
Further Information

Publication History

Publication Date:
18 September 2002 (online)

Both enantiomers of erythro methyl or ethyl 3-hydroxy-2-methylbutanoate were prepared by reaction of lithium dimethylcuprate with enantiomerically pure cis-2,3-epoxybutanoic esters derived from L- or D- threonine.

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