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Synthesis 1988; 1988(6): 485-486
DOI: 10.1055/s-1988-27618
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Palladium-Catalyzed Coupling Reaction of N-Heteroaryl Halides with Functionalized Alkylzinc Iodides

Takao Sakamoto* , Sumiko Nishimura, Yoshinori Kondo, Hiroshi Yamanaka
  • *Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980, Japan
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Publication Date:
20 August 2002 (online)

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The reaction of N-heteroaryl halides with ω-ethoxycarbonyl- and ω-chloroalkylzinc iodides, prepared from the corresponding alkyl iodides with zinc-copper couple, in the presence of dichlorobis(triphenylphosphine)palladium in N,N-dimethylacetamide/benzene yielded C-(ω-ethoxycarbonyl)- and C-(ω-chloroalkyl)-N-heteroarenes.

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