Cyanogen Bromide-Dimethylaminopyridine (CAP): A Convenient Source of Positive Cyanide for the Synthesis of 2-Cyanoimidazoles

Jeffrey P. Whitten; James R. Mccarthy; Donald P. Matthews

doi:10.1055/s-1988-27609

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Synthesis 1988; 1988(6): 470-472
DOI: 10.1055/s-1988-27609

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Cyanogen Bromide-Dimethylaminopyridine (CAP): A Convenient Source of Positive Cyanide for the Synthesis of 2-Cyanoimidazoles

Jeffrey P. Whitten^* , James R. Mccarthy, Donald P. Matthews

^*Merrell Dow Research Institute, Indianapolis Center, Indianapolis, IN 46268-0470, USA

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Publication Date:
20 August 2002 (online)

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Dimethylaminopyridine activates cyanogen bromide towards C-C bond formation by forming 1-cyano-4-dimethylaminopyridinium bromide. The latter serves as a convenient reagent for the synthesis of 2-cyanoimidazoles.

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