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Synthesis 1988; 1988(5): 388-389
DOI: 10.1055/s-1988-27584
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A Convenient Synthesis of Pyrido[3,4-g]isoquinoline via ortho-Directed Metallation/Dimerization

Véronique Bolitt* , Charles Mioskowski, S. Pulla Reddy, J. R. Falck
  • *Laboratoire de Chimie-Bioorganique, Faculté de Pharmacie, 74 route du Rhin, BP 10, F-67048 Strasbourg Cedex, France
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Publication Date:
20 August 2002 (online)

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A practical synthesis of pyrido[3,4-g]isoquinoline was realized by a novel ortho-metallation/dimerization of N,N-diethylnicotinamide (or N,N-diethylisonicotinamide), hydriodic acid reduction of the resultant diazaanthraquinone, and catalytic dehydrogenation.

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