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Synthesis 1988; 1988(2): 133-135
DOI: 10.1055/s-1988-27490
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A Facile Synthesis of 2- and 3-Hydroxyalkylseleno Compounds

Sang-Ihn Kang* , Colin Paul Spears
  • *Department of Medicine, University of Southern California, Comprehensive Cancer Center, Los Angeles, CA 90033, USA
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Publication History

Publication Date:
20 August 2002 (online)

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2-Hydroxyethylseleno and 3-hydroxypropylseleno compounds (selenides 6-9) have been prepared in good yields employing 2-hydroxyethyl and 3-hydroxypropyl selenocyanates (4 and 5). Several types of electrophilic substrates that reacted with the selenolate anions generated from 4 and 5 in situ in the presence of sodium borohydride included alkyl, benzylic, activated aromatic, benzoyl, and picolinyl halides.

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