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Synthesis 1987; 1987(5): 512-514
DOI: 10.1055/s-1987-28530
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A Convenient Synthesis of 2,3-Disubstituted Benzo[b][1,8]naphthyridines; A Novel Annelation Reaction of 2,3-Disubstituted Quinolines

Ranjan P. Srivastava* , Neelima  , A. P. Bhaduri
  • *Medicinal Chemistry Division, Central Drug Research Institute, Lucknow-226001, India
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Publication Date:
18 September 2002 (online)

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2-Chloro-3-(2-substituted 2-cyanovinyl)quinolines undergo cyclization on reaction with an excess of a secondary amine to give 3-substituted 2-aminobenzo[b][1,8]naphthyridines in moderate to high yields.

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